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A big one is strength training, and actually the literal act of contracting the muscle will independently cause the GLUT4 receptor to translocate to the membrane

This transition isnt just about swapping one medication for another

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RHR is typically between 48-52 bpm and has been around 54-55 since starting, and my max HR during lifts/hiking went from 165 to 169-170bpm

While moderate treatment typically results in non-permanent damage 16 , longer treatment times can induce, e.g ., apoptosis 17

287 : 897902 Stevens MJ, Lattimer SA, Feldman EL, Helton ED, Millington DS, Sima AA et al